Supernatural is the longest running show in the supernatural genre, running from 2004 to 2018. This is a breakdown of four main and reoccuring characters.
Sam is one of the two main characters in supernatural
Dean is the brother of sam and is the second main character of supernatural
a most re-occuring character of Supernatural acts as a third brother to the Winchesters
a re-occuring character in supernatural who acts as a little sister to the Winchester